斑疹傷寒立克次氏體IgG ELISA試劑盒

Rickettsia prowazekii IgG ELISA Kit

廣州健侖生物科技有限公司

主要用途：用于檢測(cè)人血清中的斑疹傷寒立克次氏體 IgG 抗體

產(chǎn)品規(guī)格：96人份/盒

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斑疹傷寒立克次氏體IgG ELISA試劑盒

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【公司名稱(chēng)】 廣州健侖生物科技有限公司
【】    楊永漢 
【】 
【騰訊 】 2042552662
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號(hào)二期2幢101-3室
【企業(yè)文化】

霍華德·休斯醫(yī)學(xué)研究所的研究員Nudler說(shuō)，他的團(tuán)隊(duì)的研究表明，eEF1A1通過(guò)招募一個(gè)關(guān)鍵轉(zhuǎn)錄因子對(duì)熱休克基因激活轉(zhuǎn)錄。它也穩(wěn)定了HSP的mRNA，并幫助這些RNA轉(zhuǎn)出細(xì)胞核并將它們傳遞到細(xì)胞的核糖體中用于蛋白質(zhì)的合成。Nudler說(shuō)，以這種方式，eEF1A1掌管了響應(yīng)于應(yīng)力制造HSP的整個(gè)過(guò)程。然后HSP結(jié)合到其他的蛋白質(zhì)中，阻止其毒性聚集。
該eEF1A蛋白在不同的組織中被表達(dá)為兩個(gè)類(lèi)似的形式，1和2。Nudler及其同事表明，例如，運(yùn)動(dòng)神經(jīng)元表達(dá)形式2(eEF1A2)，其不支持熱休克反應(yīng)。他們認(rèn)為，這就是為什么這些特殊細(xì)胞無(wú)法安裝熱休克反應(yīng)的原因，因此這些運(yùn)動(dòng)神經(jīng)元特別容易受到壓力和疾病，如ALS。在藥物開(kāi)發(fā)所面臨的挑戰(zhàn)將是通過(guò)調(diào)節(jié)eEF1A的活性恢復(fù)運(yùn)動(dòng)神經(jīng)元的熱休克反應(yīng)。
Nudler實(shí)驗(yàn)室在這項(xiàng)研究中使用的是各種人類(lèi)和小鼠細(xì)胞系。
人一旦通過(guò)練習(xí)掌握了一個(gè)動(dòng)作，之后就能簡(jiǎn)單重復(fù)了。這說(shuō)明大腦擁有運(yùn)動(dòng)學(xué)習(xí)功能，能形成新的運(yùn)動(dòng)記憶。日本研究人員日前報(bào)告說(shuō)，他們?cè)诖竽X皮質(zhì)運(yùn)動(dòng)區(qū)發(fā)現(xiàn)了與運(yùn)動(dòng)記憶有關(guān)的腦活動(dòng)的形成機(jī)制。
高知工科大學(xué)等機(jī)構(gòu)的研究人員在新一期美國(guó)《神經(jīng)科學(xué)雜志》上發(fā)表了他們的研究成果。在實(shí)驗(yàn)中，研究人員讓受試者用手抓住機(jī)器人的機(jī)械臂，將屏幕上的光標(biāo)從開(kāi)始點(diǎn)筆直地移動(dòng)到目的地，此外還通過(guò)機(jī)械臂對(duì)受試者施加外部干擾，然后利用經(jīng)顱磁刺激技術(shù)觀察受試者大腦皮質(zhì)運(yùn)動(dòng)區(qū)的活動(dòng)發(fā)生了何種變化。

Nudler, a Howard Hughes Medical Institute researcher, said his team's latest study shows that eEF1A1 activates transcription by activating a critical transcription factor on heat shock genes. It also stabilizes HSP mRNA and helps to transfer these RNAs out of the nucleus and deliver them to the cell's ribosomes for protein synthesis. In this way, Nudler said, eEF1A1 is in charge of the entire process of making HSPs in response to stress. The HSP then binds to other proteins, preventing its toxic build-up.
The eEF1A protein is expressed in two different forms, 1 and 2, in different tissues. Nudler and colleagues show that, for example, motor neuron expression 2 (eEF1A2), which does not support the heat shock response. This is why they think these special cells are unable to install the heat shock response, they think, and are therefore particularly vulnerable to stress and disease such as ALS. The challenge in drug development will be to restore the heat shock response of motor neurons by modulating the activity of eEFlA.
Nudler Laboratories used a variety of human and mouse cell lines in this study.
Once a person masters an action through practice, it can be simply repeated. This shows that the brain has a motor learning function, can form a new memory. Japanese researchers recently reported that they found a mechanism for the formation of motor activity associated with motor memory in the motor cortex.
Researchers at institutions such as Kochi University of Technology published their findings in a new issue of the Journal of Neuroscience. In the experiment, the researcher allowed the subject to grab the robotic arm with his hand, move the cursor on the screen straight from the starting point to the destination, and additionally subject the subject to external disturbances through the robotic arm, Cranial magnetic stimulation technique was used to observe changes in the activity of the motor cortex in the subject.