諾如病毒檢測試劑盒（免疫捕獲法）

廣州健侖生物科技有限公司

主要用途：用于檢測糞便標本中的諾如病毒抗原，以支持諾如病毒感染的診斷。

產品規格：20T/盒

存儲條件：2-30℃

諾如病毒檢測試劑盒（免疫捕獲法）

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【產品介紹】

二維碼掃一掃

【公司名稱】 廣州健侖生物科技有限公司
【】    楊永漢 
【】 
【騰訊 】 2042552662
【公司地址】 廣州清華科技園創新基地番禺石樓鎮創啟路63號二期2幢101-3室
【企業文化】

低水平氧氣促進HIF-1α的產生與活化，它以兩種方式保護細胞。首先，它開啟一些基因產生蛋白幫助細胞適應氧氣不足。它也能停止DNA復制，防止細胞分裂并增加更多需氧細胞到一個已經很惡劣的環境中。
了解某些細胞忽略HIF-1α的警告并且繼續分裂，Gregg Semenza博士及其團隊尋找HIF-1α與Cdk1、Cdk2之間的關系，這一蛋白已知調節細胞分裂的決定。他們發現HIF-1α與兩者可以相互作用，但是Cdk1增加HIF-1α水平，而Cdk2減低HIF-1α水平。
Semenza的團隊懷疑Cdk1與Cdk2按照HIF-1α的指示行事通過細胞的微型“垃圾處理器”稱為蛋白酶體標記或者不標記毀滅。但是，當研究人員限制蛋白酶體的功能后，他們發現并沒有改變HIF-1α的水平。相反，結果證明是Cdk1與Cdk2通過細胞的溶酶體標記或者不標記毀滅改變了HIF-1α水平。就他們所知，這是*次發現溶酶體牽涉到細胞的分裂決定中。
值得注意的是，在某些腫瘤細胞中，Cdk2能夠增加HIF-1α的水平同時也刺激其基因激活作用。有效效應是細胞連續分裂同時應付低氧水平。在培養的細胞中，藥物抑制Cdk1以防止HIF-1α水平的下降，并且恢復停止細胞分裂的能力，揭示它們也許能有效治療某些腫瘤。

Low levels of oxygen promote HIF-1α production and activation, which protects cells in two ways. First, it turns on some gene-producing proteins to help cells adapt to oxygen deficiency. It also stops DNA replication, prevents cell division and adds more aerobic cells to an already harsh environment.
Knowing some cells ignore the warning of HIF-1α and continue to divide, Dr. Gregg Semenza and his team looked for a relationship between HIF-1α and Cdk1, Cdk2, a protein known to regulate cell division. They found that HIF-1α interacted with both, but Cdk1 increased HIF-1α levels and Cdk2 decreased HIF-1α levels.
Semenza's team suspects that Cdk1 and Cdk2, acting on HIF-1α's targets, are called proteasome tags or unmarked annihilation through the cells' tiny "garbage disposers." However, when researchers limited proteasome function, they found that they did not alter HIF-1α levels. Conversely, the results demonstrate that altering HIF-1Î ± levels by lysosomal or unlabeled destruction of Cdk1 and Cdk2 by cells. To the best of their knowledge, this is the first discovery that lysosomes are involved in cell division decisions.
It is noteworthy that in some tumor cells, Cdk2 can increase the level of HIF-1α and also stimulate its gene activation. The effective effect is the continuous division of cells while dealing with hypoxia levels. In cultured cells, the drug inhibits Cdk1 to prevent a decrease in HIF-1α levels and resumes its ability to stop cell division, revealing that they may be effective in treating certain tumors.