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除了這項研究之外，去年來自加州大學舊金山分校的研究人員提出了一個相似的名稱：CRISPRi，他們發現當缺失核酸內切酶活性的Cas9與一種導向RNA共表達時候，會產生一種DNA識別復合物，這種復合物能特異性干擾轉錄延伸，RNA聚合酶結合，或轉錄因子結合。
由此研究人員研發出了這種CRISPRi系統，這一系統能有效抑制大腸桿菌中靶向基因的表達，并且不會出現脫靶效應。而且利用CRISPRi，還可以同時抑制多個靶基因，這種作用也是可逆。研究人員還證明，該系統也適用于哺乳動物細胞中的基因表達抑制。
加州大學圣迭戈分校(University of California, San Diego)醫學院研究人員針對自閉癥研究出一套比較新銳的理論，并對其進行了實際測試。研究結果顯示，自閉癥實際上是由異常的細胞通訊導致的，使用問世已逾百年的治療嗜睡癥的藥物，可以恢復患有自閉癥的老鼠體內的細胞活動，消除老鼠的神經失調癥狀。參與實驗的老鼠年齡相當于人類30歲左右。相關研究成果在2014年6月17日的在線刊物《平移精神病學(Translational Psychiatry)》中發表。
醫學、兒科與病理學教授、羅伯特·納維奧(Robert K. Naviaux)博士為該研究的主要負責人，他表示：“這一發現與此前認為的自閉癥是由內部原因導致的理論十分契合。在已知的與自閉癥有關的致病原因中，有20%的遺傳因素，但大部分病因并非如此。將基因與環境分離開思考并不合理。實際上，基因與環境會互相作用，作用的結果就是新陳代謝。”
納維奧還提到：“自閉癥的普遍癥狀是代謝紊亂。細胞有代謝物環(halo of metabolites)和核苷酸環繞，所謂的代謝物環是由參與新陳代謝的微小分子組成的。”

In addition to the study, researchers from the University of California, San Francisco, last year proposed a similar name, CRISPRi, who found that a DNA lacking endonuclease co-expressed with a targeting RNA produced a DNA Recognition complexes that specifically interfere with transcriptional elongation, RNA polymerase binding, or transcription factor binding.
As a result, the researchers developed the CRISPRi system, which effectively inhibits the expression of the targeted genes in E. coli and does not show off-target effects. And using CRISPRi, you can also inhibit multiple target genes, this effect is also reversible. The researchers also demonstrated that the system is also suitable for gene expression inhibition in mammalian cells.
Researchers at the University of California, San Diego Medical School developed a set of cutting-edge theories of autism and conducted practical tests. The results show that autism is actually caused by abnormal cell communication, the use of more than a century has come out of the treatment of narcolepsy drugs, can restore autism in mice with cell activity in vivo, to eliminate symptoms of neurological disorders in mice . The age of the mice involved in the experiment is about 30 years old. Relevant research results are published in the June 17, 2014 online translation "Translational Psychiatry."
Robert K. Naviaux, MD, Ph.D., professor of medicine, pediatrics and pathology, is the lead investigator for the study. "The finding and the previously thought autism is due to internal causes Fit in. Among the known causes of autism-related causes of disease, there are 20% of genetic factors, but most of the causes are not the same genetically isolated from the environment is not reasonable thinking.In fact, the genes and the environment will be mutually Effect, the result of the role of metabolism. "
Navio also mentioned: "The most common symptom of autism is metabolic disorder, where cells have halo of metabolites and nucleotides that are made up of tiny molecules that are involved in metabolism."